Increased spatial coupling of integrin and collagen IV in the immunoresistant clear-cell renal-cell carcinoma tumor microenvironment
Alex C. Soupir, Mitchell T. Hayes, Taylor C. Peak, Oscar Ospina, Nicholas H. Chakiryan, Anders E. Berglund, Paul A. Stewart, Jonathan Nguyen, Carlos Moran Segura, Natasha L. Francis, Paola M. Ramos Echevarria, Jad Chahoud, Roger Li, Kenneth Y. Tsai, Jodi A. Balasi, Yamila Caraballo Peres, Jasreman D · 2024
Read Increased spatial coupling of integrin and collagen IV in the immunoresistant clear-cell renal-cell carcinoma tumor microenvironment by Alex C. Soupir, Mitchell T. Hayes, Taylor C. Peak, Oscar Ospina, Nicholas H. Chakiryan, Anders E. Berglund, Paul A. Stewart, Jonathan Nguyen, Carlos Moran Segura, Natasha L. Francis, Paola M. Ramos Echevarria, Jad Chahoud, Roger Li, Kenneth Y. Tsai, Jodi A. Balasi, Yamila Caraballo Peres, Jasreman D (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11622564.txt.
Description
Alex Soupir and co-authors map why kidney cancers resist immunotherapy, using spatial gene reading at cellular detail, in a 2024 study. Clear cell renal cell carcinoma often responds to immune drugs at first. Resistance then develops in most patients. The tumor's neighborhood, its microenvironment, likely shelters that resistance. Ordinary sequencing grinds that geography away.
Spatial imaging preserved the layout of tumor and stroma in twenty-one tumors. Samples came from patients before and after immunotherapy. Surviving tumors showed tighter coupling between integrin signals and collagen IV. That pairing may wall immune cells out. The map suggests targets for breaking the shield. Oncologists gain a spatial clue to a stubborn problem.
Catalog record
| CREATOR | Alex C. Soupir, Mitchell T. Hayes, Taylor C. Peak, Oscar Ospina, Nicholas H. Chakiryan, Anders E. Berglund, Paul A. Stewart, Jonathan Nguyen, Carlos Moran Segura, Natasha L. Francis, Paola M. Ramos Echevarria, Jad Chahoud, Roger Li, Kenneth Y. Tsai, Jodi A. Balasi, Yamila Caraballo Peres, Jasreman D |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 65 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |