Silencing SMAD4 inhibits inflammation and ferroptosis in asthma by blocking the IL-17A signaling pathway
Xingyu Rao, Hong Luo, Kaiyuan Luo, Chaohua Hu · 2024
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Description
Xingyu Rao and co-authors show that switching off a gene called SMAD4 calms asthma-like disease in mice and cells. Their 2024 study uses an allergen-driven mouse model and a cell model dosed with an immune signal. SMAD4 sits in a pathway long tied to asthma, but its exact role was unclear.
The gene ran high in both models. Silencing it eased lung damage, cut inflammatory cell influx, and lowered a panel of inflammatory factors. It also suppressed ferroptosis, an iron-linked form of cell death. The benefit ran through blocking the IL-17A signaling path. Adding that signal back reversed the gains, confirming the route. The authors float SMAD4 as a therapy target.
Catalog record
| CREATOR | Xingyu Rao, Hong Luo, Kaiyuan Luo, Chaohua Hu |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 44 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |