Atg5-Mediated Lipophagy Induces Ferroptosis in Corneal Epithelial Cells in Dry Eye Disease
Xin Zuo, Hao Zeng, Xue Yang, Dalian He, Bowen Wang, Jin Yuan · 2024
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Description
Six authors, led by Xin Zuo, trace a self-eating process that kills surface cells in dry eye disease in this 2024 paper. Dry eye inflames the cornea, and a form of cell death called ferroptosis, driven by iron and fat damage, has been tied to that inflammation. Autophagy, the cell's recycling system, was suspected of feeding it.
The team built dry eye models in mice and in human corneal cells stressed with salty medium. Gene and lipid scans showed fat handling gone awry. They then dialed a gene called Atg5 up and down. When active, Atg5 drove lipophagy, the eating of lipid droplets, and that process fed the iron-driven death of surface cells. Blocking the chain eased the damage. The study adds a target for a disease that affects hundreds of millions of people.
Catalog record
| CREATOR | Xin Zuo, Hao Zeng, Xue Yang, Dalian He, Bowen Wang, Jin Yuan |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 48 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |