Genome-wide Mendelian randomization identifies drugs associated with body height
Li Xi, Ruoqian Cheng, Miaoying Zhang, Zhou Pei, Jiangfeng Ye, Zhuhui Zhao · 2024
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Description
Li Xi and co-authors used genetic methods in 2024 to screen for drugs linked to body height. Height is a classic trait shaped by genes and early-life conditions. No systematic screen had looked for drugs that interact with height-related genes.
Using large genetic data sets from several populations, they tested thousands of genes and found more than two hundred with causal links to height. Some were already known from short stature studies, others were new. They then matched those genes to drugs that act on them. Some matched drugs are known to aid growth, while others, including steroids and some cancer drugs, are known to slow it. Many matches had never been tied to height before.
Catalog record
| CREATOR | Li Xi, Ruoqian Cheng, Miaoying Zhang, Zhou Pei, Jiangfeng Ye, Zhuhui Zhao |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 36 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |