Nuclear factor erythroid 2-related factor 2 alleviates lung endothelial cells injury by inhibition of ferroptosis
Xiaotong Yin, Chongbing Yan, Bowen Weng, Hao Luo, Cheng Cai · 2024
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Description
Xiaotong Yin, Chongbing Yan, Bowen Weng, Hao Luo, and Cheng Cai test whether a master antioxidant switch can shield lung cells from iron-driven death. Their 2024 study addresses oxygen injury in premature babies: life-saving oxygen and ventilation raise reactive oxygen species, damaging fragile lungs, and no preventive treatment exists. Ferroptosis, a cell death driven by iron and oxygen radicals, is suspected to be a key mechanism.
The switch, Nrf2, governs both the injury response and ferroptosis defenses. In human lung vessel cells exposed to high oxygen, the team tracked mitochondrial shape changes and the death pathway's markers under different interventions. Their title states the finding: raising Nrf2 activity eased cell injury by holding ferroptosis back. The work nominates the switch as a drug target for premature lung disease.
Catalog record
| CREATOR | Xiaotong Yin, Chongbing Yan, Bowen Weng, Hao Luo, Cheng Cai |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 27 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |