Identification of a dengue 2 virus envelope protein receptor in Aedes aegypti critical for viral midgut infection
Asher M. Kantor, Octavio A. C. Talyuli, William R. Reid, Patricia Hessab Alvarenga, Jasmine Booker, Jingyi Lin, Alexander W. E. Franz, Carolina Barillas-Mury · 2024
Read Identification of a dengue 2 virus envelope protein receptor in Aedes aegypti critical for viral midgut infection by Asher M. Kantor, Octavio A. C. Talyuli, William R. Reid, Patricia Hessab Alvarenga, Jasmine Booker, Jingyi Lin, Alexander W. E. Franz, Carolina Barillas-Mury (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11621822.txt.
Description
Asher Kantor and seven co-authors identify a mosquito protein that dengue virus uses to infect the gut in this 2024 paper. For dengue to spread, the virus must first take hold in the midgut of the Aedes aegypti mosquito. The team tested whether the virus binds a specific gut protein directly. A single protein of about 31 kilodaltons caught the virus, and mass checks named it AAEL011180.
Blocking the protein's expression in the gut stopped the virus from binding. The viral surface protein also bound the purified receptor tightly in lab measures. The gene is essential, so only females with one working copy could be bred. Lowering the receptor further in those females cut the share that got infected. A partner heat shock protein played a supporting role in the same step. The authors name this receptor a key gate for dengue infection in the mosquito.
Catalog record
| CREATOR | Asher M. Kantor, Octavio A. C. Talyuli, William R. Reid, Patricia Hessab Alvarenga, Jasmine Booker, Jingyi Lin, Alexander W. E. Franz, Carolina Barillas-Mury |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 49 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |