Mouse embryonic kidney transplantation identifies maturation defects in the medulla
Hiroshi Ide, Koichiro Miike, Tomoko Ohmori, Kosuke Maruyama, Yuichiro Izumi, Shunsuke Tanigawa, Ryuichi Nishinakamura · 2024
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Description
Hiroshi Ide and six co-authors transplant embryonic mouse kidneys and find their inner region stalls at a newborn stage, in a 2024 study. Lab-grown kidney organoids mature somewhat once connected to a host's circulation, but never reach adult form. Knowing exactly where maturation stops is the first step to pushing past it.
The team profiled single cells from kidneys developing normally and harvested gene sets marking maturation of the collecting ducts and the surrounding medulla tissue. In healthy development, channel and defense genes switch on while neuronal genes switch off. Grafts barely matched the perinatal stage on these markers, and tissue staining agreed. The gene sets now serve as coordinates, letting future organoid work measure medullary maturity instead of guessing it.
Catalog record
| CREATOR | Hiroshi Ide, Koichiro Miike, Tomoko Ohmori, Kosuke Maruyama, Yuichiro Izumi, Shunsuke Tanigawa, Ryuichi Nishinakamura |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 44 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |