Differential modulation of pain and associated anxiety by GABAergic neuronal circuits in the lateral habenula
Teng Chen, Wen-Bo Liu, Sheng-Jie Zhu, Abudula Aji, Chen Zhang, Chao-Chen Zhang, Yu-Jie Duan, Jia-Xin Zuo, Zhe-Chen Liu, Hao-Jun Li, Yu-Quan Wang, Wen-Li Mi, Qi-Liang Mao-Ying, Yan-Qing Wang, Yu-Xia Chu · 2024
Read Differential modulation of pain and associated anxiety by GABAergic neuronal circuits in the lateral habenula by Teng Chen, Wen-Bo Liu, Sheng-Jie Zhu, Abudula Aji, Chen Zhang, Chao-Chen Zhang, Yu-Jie Duan, Jia-Xin Zuo, Zhe-Chen Liu, Hao-Jun Li, Yu-Quan Wang, Wen-Li Mi, Qi-Liang Mao-Ying, Yan-Qing Wang, Yu-Xia Chu (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11621741.txt.
Description
Teng Chen and co-authors trace how one small brain region links lasting pain with anxiety. Their 2024 study uses mice with facial nerve damage that mimics a human pain disorder. The region, the lateral habenula, helps govern both pain and mood. In the hurt mice, calming neurons in that region grew quiet.
Waking those neurons with light or drugs eased both pain behavior and anxiety in the mice. Signals from the region to a thalamus area eased pain mostly, with little effect on anxiety. Links among neurons inside the region eased both. A plant compound, beta-sitosterol, also acted on these neurons through a hormone receptor. The work names cell paths that future pain and anxiety treatments might target.
Catalog record
| CREATOR | Teng Chen, Wen-Bo Liu, Sheng-Jie Zhu, Abudula Aji, Chen Zhang, Chao-Chen Zhang, Yu-Jie Duan, Jia-Xin Zuo, Zhe-Chen Liu, Hao-Jun Li, Yu-Quan Wang, Wen-Li Mi, Qi-Liang Mao-Ying, Yan-Qing Wang, Yu-Xia Chu |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 53 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |