The food dye Tartrazine disrupts vascular formation both in zebrafish larvae and in human primary endothelial cells
Dinh Duy Thanh, Nguyen Bich-Ngoc, Cécile Paques, Aurélie Christian, Stéphanie Herkenne, Ingrid Struman, Marc Muller · 2024
Read The food dye Tartrazine disrupts vascular formation both in zebrafish larvae and in human primary endothelial cells by Dinh Duy Thanh, Nguyen Bich-Ngoc, Cécile Paques, Aurélie Christian, Stéphanie Herkenne, Ingrid Struman, Marc Muller (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11621646.txt.
Description
Dinh Duy Thanh and co-authors show that the food dye tartrazine disrupts blood vessel formation, in this 2024 Europe PMC paper. Tartrazine, also called E102, is a widely used coloring whose health effects are debated. The team tested it in living zebrafish larvae and in human vein cells grown in the lab.
The dye caused dose-dependent bleeding in zebrafish embryos and disrupted how vessel cells organized in the gut vein and brain. In human cells it slowed growth, tube formation and migration, again in step with dose. The authors suspect interference with Rho family pathways that control the cell skeleton. The findings may explain some reported health effects of the dye.
Catalog record
| CREATOR | Dinh Duy Thanh, Nguyen Bich-Ngoc, Cécile Paques, Aurélie Christian, Stéphanie Herkenne, Ingrid Struman, Marc Muller |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 26 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |