Bacterial products initiation of alpha-synuclein pathology: an in vitro study
Octavian Costin Ioghen, Gisela Gaina, Ioana Lambrescu, Emilia Manole, Sevinci Pop, Teodora Maria Niculescu, Oana Mosoia, Laura Cristina Ceafalan, Bogdan Ovidiu Popescu · 2024
Read Bacterial products initiation of alpha-synuclein pathology: an in vitro study by Octavian Costin Ioghen, Gisela Gaina, Ioana Lambrescu, Emilia Manole, Sevinci Pop, Teodora Maria Niculescu, Oana Mosoia, Laura Cristina Ceafalan, Bogdan Ovidiu Popescu (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11621565.txt.
Description
Parkinson's disease centers on clumps of a protein called alpha-synuclein, but what starts the clumping is unclear, and gut microbes are a suspect. The nine authors exposed dopaminergic-differentiated SH-SY5Y cells to four microbial products: lipopolysaccharide, rhamnolipid, curli CsgA, and a phenol soluble modulin. They measured cell viability, toxicity, growth, and alpha-synuclein levels with a battery of assays.
Rhamnolipid harmed cells at higher doses, cutting viability, raising toxicity, and damaging cell shape and adhesion, while raising alpha-synuclein message and protein. Lipopolysaccharide also raised alpha-synuclein levels. Curli and the modulin changed little. The authors argue that microbial molecules, above all rhamnolipid and lipopolysaccharide, can push neurons to make more alpha-synuclein, which may be one way gut microbes help start Parkinson's disease.
Catalog record
| CREATOR | Octavian Costin Ioghen, Gisela Gaina, Ioana Lambrescu, Emilia Manole, Sevinci Pop, Teodora Maria Niculescu, Oana Mosoia, Laura Cristina Ceafalan, Bogdan Ovidiu Popescu |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 49 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |