Impaired Basal Forebrain Cholinergic Neuron GDNF Signaling Contributes to Perioperative Sleep Deprivation–Induced Chronicity of Postsurgical Pain in Mice Through Regulating Cholinergic Neuronal Activity, Apoptosis, and Autophagy
Dong Wang, Shi‐Nan Wei, Lu Zhang, Zhi‐Chen Lang, Si‐Nian Wang, Bo Cheng, Yan Lu, Xiu Wang, Wei Wang, Feng‐Sheng Li, Hao Zhang · 2024
Read Impaired Basal Forebrain Cholinergic Neuron GDNF Signaling Contributes to Perioperative Sleep Deprivation–Induced Chronicity of Postsurgical Pain in Mice Through Regulating Cholinergic Neuronal Activity, Apoptosis, and Autophagy by Dong Wang, Shi‐Nan Wei, Lu Zhang, Zhi‐Chen Lang, Si‐Nian Wang, Bo Cheng, Yan Lu, Xiu Wang, Wei Wang, Feng‐Sheng Li, Hao Zhang (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11621383.txt.
Description
Dong Wang and co-authors trace how lost sleep around surgery locks in long-lasting pain through a brain support signal, in work from twenty twenty-four. Sleep deprivation near an operation raises chronic pain risk in mice. Forebrain cholinergic neurons lose activity and a growth signal, GDNF. Their death and cleanup machinery also go awry together. A mouse surgery model stages the whole sequence.
Sleep-deprived mice feel pain stronger and for far longer. Restoring the growth signal in the forebrain reverses much harm. Cell death calms and cleanup normalises under the rescue treatment. Mice lacking those cholinergic neurons resist the sleep effect entirely. The neurons are thus required for sleep loss to prolong pain. Protecting sleep around surgery may prevent chronic pain.
Catalog record
| CREATOR | Dong Wang, Shi‐Nan Wei, Lu Zhang, Zhi‐Chen Lang, Si‐Nian Wang, Bo Cheng, Yan Lu, Xiu Wang, Wei Wang, Feng‐Sheng Li, Hao Zhang |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 41 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |