Myosin VI drives arrestin-independent internalization and signaling of GPCRs
Nishaben M. Patel, Léa Ripoll, Chloe J. Peach, Ning Ma, Emily E. Blythe, Nagarajan Vaidehi, Nigel W. Bunnett, Mark von Zastrow, Sivaraj Sivaramakrishnan · 2024
Read Myosin VI drives arrestin-independent internalization and signaling of GPCRs by Nishaben M. Patel, Léa Ripoll, Chloe J. Peach, Ning Ma, Emily E. Blythe, Nagarajan Vaidehi, Nigel W. Bunnett, Mark von Zastrow, Sivaraj Sivaramakrishnan (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11621365.txt.
Description
Nishaben Patel and co-authors show that myosin VI drives a non-canonical route for GPCR uptake and signaling in a 2024 study. These receptors usually enter cells with arrestin help, a textbook path now shown to have a rival.
Myosin VI, a cytoskeletal motor, links to an adaptor that grips a tail motif found on many receptors. With a dopamine receptor as the test case, the motor controls uptake, placement, and signaling. A lock between the receptor tail and an inner loop gates motor access. Drug strength and adaptor levels tune that gate. Distinct receptor tails regulate the motor differently. The path opens new drug strategies through motor proteins.
Catalog record
| CREATOR | Nishaben M. Patel, Léa Ripoll, Chloe J. Peach, Ning Ma, Emily E. Blythe, Nagarajan Vaidehi, Nigel W. Bunnett, Mark von Zastrow, Sivaraj Sivaramakrishnan |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 78 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |