New insights into the structural role of EMILINs within the human skin microenvironment
Alvise Schiavinato, Fady Marcous, Alexandra V. Zuk, Douglas R. Keene, Sara F. Tufa, Laura M. Mosquera, Paola Zigrino, Cornelia Mauch, Beate Eckes, Katrien Francois, Julie De Backer, Nicolas Hunzelmann, Pia Moinzadeh, Thomas Krieg, Bert Callewaert, Gerhard Sengle · 2024
Read New insights into the structural role of EMILINs within the human skin microenvironment by Alvise Schiavinato, Fady Marcous, Alexandra V. Zuk, Douglas R. Keene, Sara F. Tufa, Laura M. Mosquera, Paola Zigrino, Cornelia Mauch, Beate Eckes, Katrien Francois, Julie De Backer, Nicolas Hunzelmann, Pia Moinzadeh, Thomas Krieg, Bert Callewaert, Gerhard Sengle (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11621341.txt.
Description
Skin holds its shape on a web of elastic fibers, and a family of proteins called EMILINs sits where those fibers meet their scaffolding. Alvise Schiavinato and co-authors mapped all three EMILIN proteins in human skin in 2024, using fine microscopy on samples shaped by aging, sun, scarring disease, and an inherited connective tissue disorder.
All three proteins rode on elastic fibers and on the fine fibers that anchor into the skin's basement layer, with one form touching the surface cells directly. Skin missing the scaffold protein fibrillin could not lay EMILINs down at all. One family member rose in scarred skin, and another marked the tips of fibers near hair and glands. The authors propose them as markers of skin remodeling.
Catalog record
| CREATOR | Alvise Schiavinato, Fady Marcous, Alexandra V. Zuk, Douglas R. Keene, Sara F. Tufa, Laura M. Mosquera, Paola Zigrino, Cornelia Mauch, Beate Eckes, Katrien Francois, Julie De Backer, Nicolas Hunzelmann, Pia Moinzadeh, Thomas Krieg, Bert Callewaert, Gerhard Sengle |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 51 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |