Detailed surgical description of porcine vascularized thymus lobe transplantation
M. Esad Gunes, Sho Fujiwara, Daniel H. Wolbrom, Alexander Cadelina, Susan Qudus, Dilrukshi Ekanayake-Alper, Dominik Hajosi, David H. Sachs, Greg Nowak · 2024
Read Detailed surgical description of porcine vascularized thymus lobe transplantation by M. Esad Gunes, Sho Fujiwara, Daniel H. Wolbrom, Alexander Cadelina, Susan Qudus, Dilrukshi Ekanayake-Alper, Dominik Hajosi, David H. Sachs, Greg Nowak (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11621091.txt.
Description
Gunes and co-authors give a step-by-step account of transplanting a thymus lobe in pigs, in this 2024 paper. The thymus trains immune cells, and moving it with its blood supply may teach a host to accept other grafts. That promise drives work on tolerance, in place of lifelong immune-suppressing drugs. Good surgical method is the base for all such studies.
The team used miniature swine bred to lack a key sugar marker, plus baboons, as graft sources and hosts. They freed the right or left thymus lobe in the neck, keeping its artery and veins intact. The lobe was then flushed with cold fluid before the move. Their account covers each stage so other labs can repeat the procedure in large-animal work.
Catalog record
| CREATOR | M. Esad Gunes, Sho Fujiwara, Daniel H. Wolbrom, Alexander Cadelina, Susan Qudus, Dilrukshi Ekanayake-Alper, Dominik Hajosi, David H. Sachs, Greg Nowak |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 18 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |