Model-driven exploration of poro-viscoelasticity in human brain tissue: be careful with the parameters!
Alexander Greiner, Nina Reiter, Jan Hinrichsen, Manuel P. Kainz, Gerhard Sommer, Gerhard A. Holzapfel, Paul Steinmann, Ester Comellas, Silvia Budday · 2024
Read Model-driven exploration of poro-viscoelasticity in human brain tissue: be careful with the parameters! by Alexander Greiner, Nina Reiter, Jan Hinrichsen, Manuel P. Kainz, Gerhard Sommer, Gerhard A. Holzapfel, Paul Steinmann, Ester Comellas, Silvia Budday (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11620825.txt.
Description
Alexander Greiner and co-authors model how human brain tissue responds to load when both fluid flow and slow internal relaxation are taken into account. Brain tissue is a mix of solid material and fluid that can move through it. Pinning down which effect does what has proved hard.
Simulations of squeeze and release tests on white and gray matter show that fluid effects alone cannot match the data. Adding slow relaxation gives a good fit. The study shows that volume stress, fluid flow, and relaxation are tightly coupled, so values pulled from one test can mislead. More kinds of tests will be needed to fix all parameters with confidence.
Catalog record
| CREATOR | Alexander Greiner, Nina Reiter, Jan Hinrichsen, Manuel P. Kainz, Gerhard Sommer, Gerhard A. Holzapfel, Paul Steinmann, Ester Comellas, Silvia Budday |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 58 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |