Role of the NOD1/Rip2 Signaling Pathway in Macrophage Inflammatory Activation Induced by ox-LDL
Liang Hou, Jinli Liu, Yuhui Yuan, Yanchun Ding · 2024
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Description
Liang Hou, Jinli Liu, Yuhui Yuan, and Yanchun Ding study how oxidized LDL cholesterol switches on inflammation in macrophages. These immune cells drive artery plaque growth, and their state can lean toward attack or repair. The team focuses on a sensing pathway built around the proteins NOD1 and Rip2.
Human macrophages in culture were exposed to varied doses of oxidized LDL for varied times. Pathway genes and proteins rose with dose and time, and two inflammatory signals rose with them. Blocking Rip2 with a silencing RNA cut those signals back. Oxidized LDL also shifted cell surface markers away from the repair state. The work names this pathway as a possible drug target in plaque disease.
Catalog record
| CREATOR | Liang Hou, Jinli Liu, Yuhui Yuan, Yanchun Ding |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 23 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |