ApoC-III proteoforms are associated with better lipid, inflammatory, and glucose profiles independent of total apoC-III
Pere Rehues, Josefa Girona, Montse Guardiola, Enrique Ozcariz, Núria Amigó, Roser Rosales, Yaiza Esteban, Helena Banús, Gemma Gavaldà-Alsina, Ana González-Lleó, Gemma Rojo-Martínez, Josep Ribalta · 2024
Read ApoC-III proteoforms are associated with better lipid, inflammatory, and glucose profiles independent of total apoC-III by Pere Rehues, Josefa Girona, Montse Guardiola, Enrique Ozcariz, Núria Amigó, Roser Rosales, Yaiza Esteban, Helena Banús, Gemma Gavaldà-Alsina, Ana González-Lleó, Gemma Rojo-Martínez, Josep Ribalta (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11619673.txt.
Description
Pere Rehues and co-authors published a 2024 study of seven forms, called proteoforms, of apolipoprotein C-III, a blood protein in fat metabolism, and how each form tracks health markers. The protein is known to raise blood fats, promote inflammation, and worsen insulin resistance. Most previous work measured only its total amount, or a few of its forms.
The team measured all seven forms in 875 adults from a Spanish health study of diabetes. Lipid profiles were measured with a laboratory test, and inflammatory markers came from a scan of blood proteins. Three proportions of the forms, each measured against the most common form, tracked with better markers across the board. They were linked to lower blood fats, lower inflammation, and healthier glucose handling. Those links held independently of the protein's total amount. The work suggests that the individual forms, not the total, may be the true markers of risk.
Catalog record
| CREATOR | Pere Rehues, Josefa Girona, Montse Guardiola, Enrique Ozcariz, Núria Amigó, Roser Rosales, Yaiza Esteban, Helena Banús, Gemma Gavaldà-Alsina, Ana González-Lleó, Gemma Rojo-Martínez, Josep Ribalta |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 58 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |