Evaluation of ALKBH2 and ALKBH3 gene regulation in patients with adult T-cell leukemia/lymphoma
Yuji Wada, Tadasuke Naito, Takuya Fukushima, Mineki Saito · 2024
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Description
Yuji Wada, Tadasuke Naito, Takuya Fukushima, and Mineki Saito track in 2024 two DNA-repair genes across the course of a virus-driven leukemia. The virus HTLV-1 infects many people harmlessly, but a few carriers develop adult T-cell leukemia after long quiet years. Genes of the ALKBH family help drive several cancers, so the team measured two of them in infected cell lines and patient blood.
Both genes' messages ran low in symptom-free carriers yet rebounded in acute leukemia, tracking a viral gene's activity. Their precursor messages were suppressed in infected patients only. The study also probes the chemical switches that control one of the genes.
Catalog record
| CREATOR | Yuji Wada, Tadasuke Naito, Takuya Fukushima, Mineki Saito |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 59 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |