Investigating the clinical significance of OAS family genes in breast cancer: an in vitro and in silico study
Jinjun Lu, Lu Yang, Xinghai Yang, Bin Chen, Zheqi Liu · 2024
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Description
Jinjun Lu and four co-authors study a gene family in breast cancer in a 2024 paper. The genes, called the OAS family, are best known for fighting viruses. Newer work hints they also shape how cancers grow. The team asked whether these genes mark or drive breast tumors.
They grew breast cancer cells and normal controls and read gene activity in both. All four family genes ran much higher in cancer cells and tissues. That rise tracked with lower chemical masking of the genes' start regions. Lab tests checked how the genes affect cell growth, spread, and wound closure. Public cancer databases backed the lab findings with patient data. The authors propose the family as a source of markers for early detection and tailored care.
Catalog record
| CREATOR | Jinjun Lu, Lu Yang, Xinghai Yang, Bin Chen, Zheqi Liu |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 52 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |