Stephanine Protects Against Osteoporosis by Suppressing Osteoclastogenesis via Inhibition of the RANKL—RANK Interaction
Titi Liu, Jin Li, Meiyan Duan, Ya Wang, Zhe Jiang, Chunxia Gan, Zemin Xiang, Jun Sheng, Xuanjun Wang, Huanhuan Xu · 2024
Read Stephanine Protects Against Osteoporosis by Suppressing Osteoclastogenesis via Inhibition of the RANKL—RANK Interaction by Titi Liu, Jin Li, Meiyan Duan, Ya Wang, Zhe Jiang, Chunxia Gan, Zemin Xiang, Jun Sheng, Xuanjun Wang, Huanhuan Xu (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11619157.txt.
Description
Titi Liu and co-authors test whether stephanine, a plant alkaloid, can protect bones by slowing the cells that break bone down. Their 2024 study targets the RANKL and RANK signal pair, the main switch for forming osteoclasts, the cells that resorb bone. Blocking that switch is already a proven strategy against osteoporosis.
In cell tests, stephanine bound both partners and disrupted their interaction, quieting the signals that drive osteoclast formation. Treated precursor cells then made fewer mature osteoclasts. In mice that model postmenopausal bone loss, the compound preserved bone area and cut osteoclast counts. Blood markers of bone breakdown fell while a protective marker rose. The authors propose stephanine as a natural-product lead for osteoporosis therapy, with much testing still ahead.
Catalog record
| CREATOR | Titi Liu, Jin Li, Meiyan Duan, Ya Wang, Zhe Jiang, Chunxia Gan, Zemin Xiang, Jun Sheng, Xuanjun Wang, Huanhuan Xu |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 35 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |