Protocol for Therapeutic Drug Monitoring Within the Clinical Range Using Mid-infrared Spectroscopy
Pin Dong, Kezheng Li, David J. Rowe, Thomas F. Krauss, Yue Wang · 2024
Read Protocol for Therapeutic Drug Monitoring Within the Clinical Range Using Mid-infrared Spectroscopy by Pin Dong, Kezheng Li, David J. Rowe, Thomas F. Krauss, Yue Wang (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11618749.txt.
Description
Pin Dong, Kezheng Li, David Rowe, Thomas Krauss, and Yue Wang present a recipe for reading drug levels in blood with infrared light, in a 2024 protocol paper. Clinicians adjust many drugs by measured level, but the standard method is slow, lab-bound mass spectrometry. Infrared spectroscopy is fast and specific, and could shrink to the bedside. Its enemy is background: blood's own fats, proteins, and small molecules drown the drug's signal in the mid-infrared.
Their approach strips that background away step by step, leaving the drug measurable. Using phenytoin, a seizure drug, as the test case, they quantify it in human serum at ten micrograms per milliliter, squarely in the clinical range. The authors note the background-removal trick should serve other sensing methods that fight serum noise, not just infrared ones.
Catalog record
| CREATOR | Pin Dong, Kezheng Li, David J. Rowe, Thomas F. Krauss, Yue Wang |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 29 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |