SHIV remission in macaques with early treatment initiation and ultra long-lasting antiviral activity
Michele B. Daly, Chuong Dinh, Angela Holder, Donna Rudolph, Susan Ruone, Alison Swaims-Kohlmeier, George Khalil, Sunita Sharma, James Mitchell, Jillian Condrey, Daniel Kim, Yi Pan, Kelly Curtis, Peter Williams, William Spreen, Walid Heneine, J. Gerardo García-Lerma · 2024
Read SHIV remission in macaques with early treatment initiation and ultra long-lasting antiviral activity by Michele B. Daly, Chuong Dinh, Angela Holder, Donna Rudolph, Susan Ruone, Alison Swaims-Kohlmeier, George Khalil, Sunita Sharma, James Mitchell, Jillian Condrey, Daniel Kim, Yi Pan, Kelly Curtis, Peter Williams, William Spreen, Walid Heneine, J. Gerardo García-Lerma (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11618496.txt.
Description
Michele Daly and a large team of co-authors present a 2024 study on lasting virus control in monkeys infected with a virus related to HIV. In such infections, hidden virus reservoirs resist standard drug treatment. The team reasoned that drugs reaching deep into tissues and lasting a long time might do better. They treated infected macaques soon after virus appeared in the blood, using daily pills plus long-acting injections.
All animals reached full virus suppression during treatment, which lasted four to twelve months. After treatment stopped, no virus returned over up to two years of watch, even when key immune cells were removed. One drug lingered in the blood for two years after the last dose. The authors describe the outcome as remission. They credit the early start and the very long drug action together.
Catalog record
| CREATOR | Michele B. Daly, Chuong Dinh, Angela Holder, Donna Rudolph, Susan Ruone, Alison Swaims-Kohlmeier, George Khalil, Sunita Sharma, James Mitchell, Jillian Condrey, Daniel Kim, Yi Pan, Kelly Curtis, Peter Williams, William Spreen, Walid Heneine, J. Gerardo García-Lerma |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 58 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |