Inhibition of ABCG2 prevents phototoxicity in a mouse model of erythropoietic protoporphyria
Junjie Zhu, Fu-Ying Qin, Saifei Lei, Ruizhi Gu, Qian Qi, Jie Lu, Karl E Anderson, Peter Wipf, Xiaochao Ma · 2024
Read Inhibition of ABCG2 prevents phototoxicity in a mouse model of erythropoietic protoporphyria by Junjie Zhu, Fu-Ying Qin, Saifei Lei, Ruizhi Gu, Qian Qi, Jie Lu, Karl E Anderson, Peter Wipf, Xiaochao Ma (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11618456.txt.
Description
Junjie Zhu and co-authors test a new oral drug idea in 2024 for a rare blood illness that makes skin painfully raw in sunlight. No oral drug exists for the light harm, and care options stay thin.
The illness builds up a pigment in red cells. A pump pushes that pigment out of the cells, which spreads it through the body. Blocking the pump with new oral drugs kept the pigment in check in mice bred to mimic the illness, and the mice were spared light harm. The team offers pump blocking as a fresh path to the first oral care.
Catalog record
| CREATOR | Junjie Zhu, Fu-Ying Qin, Saifei Lei, Ruizhi Gu, Qian Qi, Jie Lu, Karl E Anderson, Peter Wipf, Xiaochao Ma |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 29 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |