Conjugation of Antibodies and siRNA Duplexes to Polymer Nanoparticles via Maleimide–Thiol Chemistry
Elise · 2024
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Description
Hoover and co-authors explain how to attach antibodies and gene silencing strands to plastic nanoparticles, in work published in 2024. The catalog creator field is garbled, so the head byline governs here. Such particles can carry many kinds of cargo, and their surfaces can be tuned for each use.
The team varied buffer strength, reagent ratios, and additives to map what controls loading. Antibody loading could be tuned up to a clear ceiling, and two routes to attach them both worked. Loading of the gene strands also shifted with buffer and additive levels. Attaching both cargoes at once was shown to be possible. The work gives a basis for controlled loading on these particles.
Catalog record
| CREATOR | Elise |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 41 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |