Group 2 innate lymphoid cells are a non-redundant source of interleukin-5 required for development and function of murine B1 cells
Karoline F. Troch, Manuel O. Jakob, Patrycja M. Forster, Katja J. Jarick, Jonathan Schreiber, Alexandra Preusser, Gabriela M. Guerra, Pawel Durek, Caroline Tizian, Nele Sterczyk, Sofia Helfrich, Claudia U. Duerr, David Voehringer, Mario Witkowski, David Artis, Tim Rollenske, Andrey A. Kruglov, Mir-F · 2024
Read Group 2 innate lymphoid cells are a non-redundant source of interleukin-5 required for development and function of murine B1 cells by Karoline F. Troch, Manuel O. Jakob, Patrycja M. Forster, Katja J. Jarick, Jonathan Schreiber, Alexandra Preusser, Gabriela M. Guerra, Pawel Durek, Caroline Tizian, Nele Sterczyk, Sofia Helfrich, Claudia U. Duerr, David Voehringer, Mario Witkowski, David Artis, Tim Rollenske, Andrey A. Kruglov, Mir-F (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11618303.txt.
Description
Karoline Troch and a large team show that one group of fast-response immune cells is the sole source of a signal that B1 cells need. Their 2024 study works in mice at body barrier sites. The cells at issue react to alarm signals from surface tissues and pour out type-two signals, among them one called IL-5. B1 cells are early antibody makers that guard those same barriers. Whether other cells could cover for the fast group was unclear.
Without the fast group, B1 cells fail to develop well. A specific alarm receptor on the fast cells proves vital for making the signal. Deleting the signal gene only in those cells breaks B1 growth and antibody output. B1 cells tuned to a common surface fat also shrink in number. The work fixes one clear chain from alarm sensing to antibody defense.
Catalog record
| CREATOR | Karoline F. Troch, Manuel O. Jakob, Patrycja M. Forster, Katja J. Jarick, Jonathan Schreiber, Alexandra Preusser, Gabriela M. Guerra, Pawel Durek, Caroline Tizian, Nele Sterczyk, Sofia Helfrich, Claudia U. Duerr, David Voehringer, Mario Witkowski, David Artis, Tim Rollenske, Andrey A. Kruglov, Mir-F |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 60 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |