Hyperthermophilic xylanase and thermophilicity analysis by molecular dynamic simulation with quantum mechanics
Katewadee Boonyapakron, Braden Keiser, Kanoknart Prabmark, Katesuda Aiewviriyasakul, Nattapol Arunrattanamook, Aritsara Jaruwat, Penchit Chitnumsub, Jia-Yi Li, Tuck Seng Wong, Xin-Qing Zhao, Chen-Guang Liu, Dong-Qing Wei, Verawat Champreda · 2024
Read Hyperthermophilic xylanase and thermophilicity analysis by molecular dynamic simulation with quantum mechanics by Katewadee Boonyapakron, Braden Keiser, Kanoknart Prabmark, Katesuda Aiewviriyasakul, Nattapol Arunrattanamook, Aritsara Jaruwat, Penchit Chitnumsub, Jia-Yi Li, Tuck Seng Wong, Xin-Qing Zhao, Chen-Guang Liu, Dong-Qing Wei, Verawat Champreda (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11618197.txt.
Description
Katewadee Boonyapakron and a large team engineered a heat-loving enzyme in two thousand twenty-four that breaks down xylan, a plant fibre, at near-boiling heat. Such enzymes serve food, feed, biofuel, and pulp work. Starting from an enzyme found in a bagasse pile's microbes, they added two changes by rational design.
The new enzyme works best at eighty-five degrees and lasts far longer at ninety, with a melting point above ninety-three. It turned xylan into prebiotic sugars with sharp selectivity and a tenfold yield gain over its parent. Simulations tied the gains to stronger internal bonds and a new kind of weak interaction that fires more often.
Catalog record
| CREATOR | Katewadee Boonyapakron, Braden Keiser, Kanoknart Prabmark, Katesuda Aiewviriyasakul, Nattapol Arunrattanamook, Aritsara Jaruwat, Penchit Chitnumsub, Jia-Yi Li, Tuck Seng Wong, Xin-Qing Zhao, Chen-Guang Liu, Dong-Qing Wei, Verawat Champreda |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 56 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |