Oropharyngeal resistome remains stable during COVID-19 therapy, while fecal resistome shifts toward a less diverse resistotype
Elizaveta V Starikova, Yulia S Galeeva, Dmitry E Fedorov, Elena V Korneenko, Anna S Speranskaya, Oksana V Selezneva, Polina Y Zoruk, Ksenia M Klimina, Vladimir A Veselovsky, Maxim D Morozov, Daria I Boldyreva, Evgenii I Olekhnovich, Alexander I Manolov, Alexander V Pavlenko, Ivan E Kozlov, Oleg O Ya · 2024
Read Oropharyngeal resistome remains stable during COVID-19 therapy, while fecal resistome shifts toward a less diverse resistotype by Elizaveta V Starikova, Yulia S Galeeva, Dmitry E Fedorov, Elena V Korneenko, Anna S Speranskaya, Oksana V Selezneva, Polina Y Zoruk, Ksenia M Klimina, Vladimir A Veselovsky, Maxim D Morozov, Daria I Boldyreva, Evgenii I Olekhnovich, Alexander I Manolov, Alexander V Pavlenko, Ivan E Kozlov, Oleg O Ya (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11617248.txt.
Description
The germs in a COVID-19 patient's gut shift their drug resistance during treatment, while those in the throat hold steady, in a 2024 study by Elizaveta V. Starikova and co-authors. Resistance genes as a whole, the resistome, are a public health worry that the pandemic threw into relief.
Swabs and stool samples were read with a panel covering nearly five thousand resistance genes. Throat resistomes looked much alike across patients and barely changed over time. Gut samples fell into two distinct patterns only loosely tied to gut community types. About half the patients switched pattern within a week of therapy, most moving to the less diverse one. The contrast shows how unevenly treatment pressures act on the body.
Catalog record
| CREATOR | Elizaveta V Starikova, Yulia S Galeeva, Dmitry E Fedorov, Elena V Korneenko, Anna S Speranskaya, Oksana V Selezneva, Polina Y Zoruk, Ksenia M Klimina, Vladimir A Veselovsky, Maxim D Morozov, Daria I Boldyreva, Evgenii I Olekhnovich, Alexander I Manolov, Alexander V Pavlenko, Ivan E Kozlov, Oleg O Ya |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 80 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |