Efficacy of COVID-19 Treatments in Intensive Care Unit: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Mahmoud Alwakeel, Francois Abi Fadel, Abdelrahman Nanah, Yan Wang, Mohamed K. A. Awad, Fatima Abdeljaleel, Mohammed Obeidat, Talha Saleem, Saira Afzal, Dina Alayan, Mary Pat Harnegie, Xiaofeng Wang, Abhijit Duggal, Peng Zhang · 2024
Read Efficacy of COVID-19 Treatments in Intensive Care Unit: A Systematic Review and Meta-Analysis of Randomized Controlled Trials by Mahmoud Alwakeel, Francois Abi Fadel, Abdelrahman Nanah, Yan Wang, Mohamed K. A. Awad, Fatima Abdeljaleel, Mohammed Obeidat, Talha Saleem, Saira Afzal, Dina Alayan, Mary Pat Harnegie, Xiaofeng Wang, Abhijit Duggal, Peng Zhang (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11617054.txt.
Description
Alwakeel and a large team pooled trial evidence in twenty twenty-four on COVID-19 treatments for patients in intensive care. They gathered randomized trials from six major databases. Their main question was whether any drug group lowered deaths among the critically ill.
Forty trials covering over eleven thousand patients tested fifty treatment arms in five groups. The groups were steroids, antivirals, immune modulators, plasma therapies, and blood thinners. Only immune modulators showed a possible benefit, with deaths about seventeen percent lower. The other four groups showed no clear effect. The authors note many trials rested on weak early evidence. They urge that future pandemic trials be designed on stronger ground.
Catalog record
| CREATOR | Mahmoud Alwakeel, Francois Abi Fadel, Abdelrahman Nanah, Yan Wang, Mohamed K. A. Awad, Fatima Abdeljaleel, Mohammed Obeidat, Talha Saleem, Saira Afzal, Dina Alayan, Mary Pat Harnegie, Xiaofeng Wang, Abhijit Duggal, Peng Zhang |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 26 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |