Quantitative Muscle MRI to Monitor Disease Progression in Hypokalemic Period Paralysis
Sonja Holm-Yildiz, Thomas Krag, Tina Dysgaard, Britt Stævnsbo Pedersen, Nanna Witting, Louise Sloth Kodal, Linda Kannuberg, Jonas Jalili Pedersen, Zhe Lyu, Morten Müller Aagaard, John Vissing · 2024
Read Quantitative Muscle MRI to Monitor Disease Progression in Hypokalemic Period Paralysis by Sonja Holm-Yildiz, Thomas Krag, Tina Dysgaard, Britt Stævnsbo Pedersen, Nanna Witting, Louise Sloth Kodal, Linda Kannuberg, Jonas Jalili Pedersen, Zhe Lyu, Morten Müller Aagaard, John Vissing (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11616970.txt.
Description
Sonja Holm-Yildiz and co-authors follow a rare muscle disease over time with quantitative MRI in a 2024 study. The disease, hypokalemic periodic paralysis, is a fault in a muscle channel. It brings attacks of paralysis when blood potassium drops, and it can leave lasting weakness. How steadily the muscle itself worsens was little known, and trials of new treatments need a measure that can track that change.
Thirty-seven patients joined the follow-up study. A special MRI method measured how much of each muscle had turned to fat, a sign of decay. A fixed strength tester measured muscle force in parallel. The team describes the disease's natural course and tests whether the fat measure moves in step with decline. A scan-based marker that tracks progression would serve both clinic visits and drug trials.
Catalog record
| CREATOR | Sonja Holm-Yildiz, Thomas Krag, Tina Dysgaard, Britt Stævnsbo Pedersen, Nanna Witting, Louise Sloth Kodal, Linda Kannuberg, Jonas Jalili Pedersen, Zhe Lyu, Morten Müller Aagaard, John Vissing |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 24 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |