The Clinical Impact of NPM1 Mutations and the Effect of Concurrent Mutations in Acute Myeloid Leukemia: Unraveling the Prognostic Significance
Faten Moassass, Yahia Moualla, Bassel AL‐Halabi, Atieh Khamis, Walid Al‐achkar · 2024
Read The Clinical Impact of NPM1 Mutations and the Effect of Concurrent Mutations in Acute Myeloid Leukemia: Unraveling the Prognostic Significance by Faten Moassass, Yahia Moualla, Bassel AL‐Halabi, Atieh Khamis, Walid Al‐achkar (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11615810.txt.
Description
Faten Moassass and co-authors study a gene mutation that marks a distinct form of acute myeloid leukemia. Their 2024 paper covers Syrian patients whose leukemia cells had a normal chromosome picture. The gene, NPM1, is mutated in a large share of such cases worldwide and shapes how the disease behaves.
The team sequenced samples from one hundred newly diagnosed adults. About a fifth carried the mutation, most of a common type, with a few new variants found. They also tracked two partner mutations that often travel with it. The mix of mutations shapes prognosis and treatment choices for this leukemia subset. Local data matters because mutation rates and pairings can differ between populations, and care plans borrow strength from pooled global figures.
Catalog record
| CREATOR | Faten Moassass, Yahia Moualla, Bassel AL‐Halabi, Atieh Khamis, Walid Al‐achkar |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 25 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |