Targeting Tumor Endothelial Cells by EGCG Using Specific Liposome Delivery System Inhibits Vascular Inflammation and Thrombosis
Zi Jia, Nako Maishi, Hideki Takekawa, Aya Yanagawa Matsuda, Taisei Nakade, Takashi Nakamura, Hideyoshi Harashima, Yasuhiro Hida, Kyoko Hida · 2024
Read Targeting Tumor Endothelial Cells by EGCG Using Specific Liposome Delivery System Inhibits Vascular Inflammation and Thrombosis by Zi Jia, Nako Maishi, Hideki Takekawa, Aya Yanagawa Matsuda, Taisei Nakade, Takashi Nakamura, Hideyoshi Harashima, Yasuhiro Hida, Kyoko Hida (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11615514.txt.
Description
Zi Jia and co-authors test a green tea compound in 2024 against swelling inside tumor blood vessels. Swollen vessel walls in tumors help clots form, and clots are a leading cause of death in cancer patients. The tea compound calms swelling in lab tests, but whether it can reach tumor vessels and slow tumors was unclear.
The team packed the compound into fat bubbles built to home to tumor vessels in mice. The treated vessels made fewer swelling signals and less of a clot-linked protein. Tumors also drew in more immune cells and formed fewer clots. The results point to vessel swelling as a target worth more study in cancer care.
Catalog record
| CREATOR | Zi Jia, Nako Maishi, Hideki Takekawa, Aya Yanagawa Matsuda, Taisei Nakade, Takashi Nakamura, Hideyoshi Harashima, Yasuhiro Hida, Kyoko Hida |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 38 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |