Cross-species single-cell RNA-seq analysis reveals disparate and conserved cardiac and extracardiac inflammatory responses upon heart injury
Eric Cortada, Jun Yao, Yu Xia, Friederike Dündar, Paul Zumbo, Boris Yang, Alfonso Rubio-Navarro, Björn Perder, Miaoyan Qiu, Anthony M Pettinato, Edwin A Homan, Lisa Stoll, Doron Betel, Jingli Cao, James C Lo · 2024
Read Cross-species single-cell RNA-seq analysis reveals disparate and conserved cardiac and extracardiac inflammatory responses upon heart injury by Eric Cortada, Jun Yao, Yu Xia, Friederike Dündar, Paul Zumbo, Boris Yang, Alfonso Rubio-Navarro, Björn Perder, Miaoyan Qiu, Anthony M Pettinato, Edwin A Homan, Lisa Stoll, Doron Betel, Jingli Cao, James C Lo (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11615278.txt.
Description
Eric Cortada and co-authors compare how hearts in fish and mice react to injury, cell by cell. Their twenty twenty-four paper uses single-cell RNA reads after heart damage. Adult zebrafish regrow heart tissue, while adult mice and humans mostly scar.
Fish hearts were frozen to injure them, and mouse hearts were tied off at an artery. The team also tracked reactions in tissues far from the heart. Heart macrophages stood out as key players in the heal-or-scar choice. Some cell groups and gene programs matched across species, while others split apart. The map may show what to copy from fish for human repair.
Catalog record
| CREATOR | Eric Cortada, Jun Yao, Yu Xia, Friederike Dündar, Paul Zumbo, Boris Yang, Alfonso Rubio-Navarro, Björn Perder, Miaoyan Qiu, Anthony M Pettinato, Edwin A Homan, Lisa Stoll, Doron Betel, Jingli Cao, James C Lo |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 88 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |