Novel polymorphic and copy number diversity in the antibody IGH locus of South African individuals
Alaine A Marsden, Martin Corcoran, Gunilla Karlsson Hedestam, Nigel Garrett, Salim S Abdool Karim, Penny L Moore, Dale Kitchin, Lynn Morris, Cathrine Scheepers · 2024
Read Novel polymorphic and copy number diversity in the antibody IGH locus of South African individuals by Alaine A Marsden, Martin Corcoran, Gunilla Karlsson Hedestam, Nigel Garrett, Salim S Abdool Karim, Penny L Moore, Dale Kitchin, Lynn Morris, Cathrine Scheepers (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11615098.txt.
Description
Alaine Marsden and co-authors map fresh gene variety in the antibody heavy chain zone of South African donors in a 2024 study. That zone helps build the part of an antibody that grips germs. Its genes shift a lot from person to person, through small changes and full copies of genes.
The team read the zone in 70 donors from KwaZulu-Natal and matched eight with data on the antibodies they make. They found 161 gene forms in the germline reads, and 32 of those were new to science. The made-antibody data held 21 more new forms. Copies of genes also turned up in numbers not seen in other groups, which may shape immune response.
Catalog record
| CREATOR | Alaine A Marsden, Martin Corcoran, Gunilla Karlsson Hedestam, Nigel Garrett, Salim S Abdool Karim, Penny L Moore, Dale Kitchin, Lynn Morris, Cathrine Scheepers |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 45 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |