Dissecting Innate and Adaptive Immunity in Inflammatory Bowel Disease: Immune Compartmentalization, Microbiota Crosstalk, and Emerging Therapies
Ningning Yue, Peng Hu, Chengmei Tian, Chen Kong, Hailan Zhao, Yuan Zhang, Jun Yao, Yuqi Wei, Defeng Li, Lisheng Wang · 2024
Read Dissecting Innate and Adaptive Immunity in Inflammatory Bowel Disease: Immune Compartmentalization, Microbiota Crosstalk, and Emerging Therapies by Ningning Yue, Peng Hu, Chengmei Tian, Chen Kong, Hailan Zhao, Yuan Zhang, Jun Yao, Yuqi Wei, Defeng Li, Lisheng Wang (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11615095.txt.
Description
The gut's immune system is the body's largest, and its overreaction to food, microbes, and other triggers drives inflammatory bowel disease. Yue and nine co-authors review how the two arms of immunity, the fast innate arm and the targeted adaptive arm, go wrong in this disease. They cover the key cell types, from dendritic cells to natural lymphocytes, and how the gut's microbe community talks back to them.
Many patients still fail to respond to current immune-based biologics, which pushes the search for new targets. Fresh findings on T cell behavior may point to new cytokines to block or boost. The review ties together immune compartmentalization, the physical sorting of gut immunity, with microbe crosstalk. The authors aim the synthesis at researchers hunting therapies for patients whom today's drugs leave behind.
Catalog record
| CREATOR | Ningning Yue, Peng Hu, Chengmei Tian, Chen Kong, Hailan Zhao, Yuan Zhang, Jun Yao, Yuqi Wei, Defeng Li, Lisheng Wang |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 79 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |