Identification of biomarkers in Parkinson’s disease by comparative transcriptome analysis and WGCNA highlights the role of oligodendrocyte precursor cells
Fa-Li Zhang, Ai-Ying Li, Yi-Lin Niu, Kai Zhang, Ming-Hui Zhao, Jiao-Jiao Huang, Wei Shen · 2024
Read Identification of biomarkers in Parkinson’s disease by comparative transcriptome analysis and WGCNA highlights the role of oligodendrocyte precursor cells by Fa-Li Zhang, Ai-Ying Li, Yi-Lin Niu, Kai Zhang, Ming-Hui Zhao, Jiao-Jiao Huang, Wei Shen (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11615075.txt.
Description
Fa-Li Zhang and six co-authors mined gene data in 2024 for early drivers of Parkinson's disease outside the dopamine neurons that usually draw focus. Their attention fell on oligodendrocyte precursor cells, which mature into the brain's insulation makers. Network analysis of bulk data hinted these cells falter early in the disease. Single-cell data from patients then traced how the cells change and talk to others.
Key genes overlapped between the precursor cells' network hubs and their changed genes, but not in mature cells, suggesting the precursors react first. A scoring model picked five candidate markers from those genes. The authors present the cells as an underwatched player in Parkinson's and the markers as leads for early detection work.
Catalog record
| CREATOR | Fa-Li Zhang, Ai-Ying Li, Yi-Lin Niu, Kai Zhang, Ming-Hui Zhao, Jiao-Jiao Huang, Wei Shen |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 36 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |