Comparison of a SARS-CoV-2 mRNA booster immunization containing additional antigens to a spike-based mRNA vaccine against Omicron BA.5 infection in hACE2 mice
Jacklyn R. Hurst, Maedeh Naghibosadat, Patrick Budowski, Jun Liu, Philip Samaan, Frans Budiman, Alexandra Kurtesi, Fredo Qi, Haritha Menon, Rajesh Krishnan, Jumai Abioye, Anne-Claude Gingras, Mario Ostrowski, Natalia Martin Orozco, Robert A. Kozak, Nagarajan Raju, Nagarajan Raju, Nagarajan Raju · 2024
Read Comparison of a SARS-CoV-2 mRNA booster immunization containing additional antigens to a spike-based mRNA vaccine against Omicron BA.5 infection in hACE2 mice by Jacklyn R. Hurst, Maedeh Naghibosadat, Patrick Budowski, Jun Liu, Philip Samaan, Frans Budiman, Alexandra Kurtesi, Fredo Qi, Haritha Menon, Rajesh Krishnan, Jumai Abioye, Anne-Claude Gingras, Mario Ostrowski, Natalia Martin Orozco, Robert A. Kozak, Nagarajan Raju, Nagarajan Raju, Nagarajan Raju (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11614295.txt.
Description
Jacklyn Hurst and a large team of co-authors tested a broader COVID-19 booster in mice in a 2024 paper. Most vaccines target only the spike protein, which keeps changing. Their booster adds a fused piece of two more viral proteins, nucleoprotein and membrane, aiming for wider protection against variants like Omicron BA.5.
Mice first vaccinated with spike-only shots got either the same booster or the widened one. Both boosters nearly stopped infectious virus in mouth swabs and cut virus levels in lung and nose after challenge. Lung damage was equally well prevented. The widened booster also neutralized several variants in lab tests much like the spike-only one. The authors see multi-antigen shots as a viable next step.
Catalog record
| CREATOR | Jacklyn R. Hurst, Maedeh Naghibosadat, Patrick Budowski, Jun Liu, Philip Samaan, Frans Budiman, Alexandra Kurtesi, Fredo Qi, Haritha Menon, Rajesh Krishnan, Jumai Abioye, Anne-Claude Gingras, Mario Ostrowski, Natalia Martin Orozco, Robert A. Kozak, Nagarajan Raju, Nagarajan Raju, Nagarajan Raju |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 90 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |