Salivary gland protective and antiinflammatory effects of genistein in Sjögren’s syndrome by inhibiting Xist/ACSL4-mediated ferroptosis following binding to estrogen receptor-alpha
Tianjiao Mao, Wei Wei, Bo Chen, Yixin Chen, Shuqi Liang, Guiping Chen, Zhuoyuan Liu, Xiaodan Wu, Lihong Wu, Xiaomeng Li, Nobumoto Watanabe, Kevin H Mayo, Janak L Pathak, Jiang Li · 2024
Read Salivary gland protective and antiinflammatory effects of genistein in Sjögren’s syndrome by inhibiting Xist/ACSL4-mediated ferroptosis following binding to estrogen receptor-alpha by Tianjiao Mao, Wei Wei, Bo Chen, Yixin Chen, Shuqi Liang, Guiping Chen, Zhuoyuan Liu, Xiaodan Wu, Lihong Wu, Xiaomeng Li, Nobumoto Watanabe, Kevin H Mayo, Janak L Pathak, Jiang Li (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11613825.txt.
Description
Tianjiao Mao and thirteen co-authors report a 2024 study on a soy compound that may calm Sjögren's syndrome, an autoimmune attack on the spit and tear glands. Options for the disease are few. The compound, genistein, latches onto an estrogen catcher, and the team traced a chain from that catch to a form of cell death by iron and fat rusting in gland cells.
In mice bred for the disease and in gland cells stirred up in dishes, the compound eased dry mouth signs and tissue harm. Lab work tied its action to a long RNA that drives the death chain: blocking that RNA's partner gene cut the rusting death. Binding tests confirmed the compound grips the catcher as proposed. The authors name the chain a drug lead.
Catalog record
| CREATOR | Tianjiao Mao, Wei Wei, Bo Chen, Yixin Chen, Shuqi Liang, Guiping Chen, Zhuoyuan Liu, Xiaodan Wu, Lihong Wu, Xiaomeng Li, Nobumoto Watanabe, Kevin H Mayo, Janak L Pathak, Jiang Li |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 42 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |