Embracing sex-specific differences in engineered kidney models for enhanced biological understanding of kidney function
Charlotte Veser, Aurélie Carlier, Vanessa Dubois, Silvia M Mihăilă, Sangita Swapnasrita · 2024
Read Embracing sex-specific differences in engineered kidney models for enhanced biological understanding of kidney function by Charlotte Veser, Aurélie Carlier, Vanessa Dubois, Silvia M Mihăilă, Sangita Swapnasrita (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11613810.txt.
Description
Charlotte Veser and four co-authors argue that lab-grown kidney models should build in sex differences, in a 2024 review. Kidneys clear drugs and toxins, so models of them guide drug tests. Yet kidney work varies much by person, and sex shapes that work in deep ways. Most lab models still skip sex as a factor.
Skipping sex risks missing how disease starts, how it runs, and how drugs act or harm in each sex. The review maps known sex-linked traits of the kidney, from cells to whole tissue. It then lays out design rules for models that carry those traits. The goal is sharper models and safer, more tailored care for each patient.
Catalog record
| CREATOR | Charlotte Veser, Aurélie Carlier, Vanessa Dubois, Silvia M Mihăilă, Sangita Swapnasrita |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 71 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |