Knockout of B2M in combination with PD-L1 overexpression protects MSC-derived new islet β cells from graft rejection in the treatment of canine diabetes mellitus
Pengxiu Dai, Yi Wu, Qingjie Du, Juanjuan Du, Keyi Wang, Ruiqi Chen, Xiancheng Feng, Chen Chen, Xinke Zhang · 2024
Read Knockout of B2M in combination with PD-L1 overexpression protects MSC-derived new islet β cells from graft rejection in the treatment of canine diabetes mellitus by Pengxiu Dai, Yi Wu, Qingjie Du, Juanjuan Du, Keyi Wang, Ruiqi Chen, Xiancheng Feng, Chen Chen, Xinke Zhang (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11613808.txt.
Description
Pengxiu Dai and co-authors edit dog stem cells so that insulin-making cells grown from them can dodge rejection, in a study from 2024. Donor stem cells tend to be spotted and cleared by the body, more so after they mature. That rejection cuts how long a graft can treat diabetes.
The team knocked out a gene called B2M and raised levels of a second gene, PD-L1, in fat stem cells from dogs. The edited cells kept normal traits but drew less immune attack. Grown into new islet beta cells, they matured better than before. Placed in diabetic dogs inside a pre-grown blood-rich pouch, the cells drew fewer immune cells. The authors see this as a path to longer-lasting cell grafts.
Catalog record
| CREATOR | Pengxiu Dai, Yi Wu, Qingjie Du, Juanjuan Du, Keyi Wang, Ruiqi Chen, Xiancheng Feng, Chen Chen, Xinke Zhang |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 75 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |