Autoantibody profiles in Alzheimer´s, Parkinson´s, and dementia with Lewy bodies: altered IgG affinity and IgG/IgM/IgA responses to alpha-synuclein, amyloid-beta, and tau in disease-specific pathological patterns
Luisa Knecht, Katrine Dalsbøl, Anja Hviid Simonsen, Falk Pilchner, Jean Alexander Ross, Kristian Winge, Lisette Salvesen, Sara Bech, Anne-Mette Hejl, Annemette Løkkegaard, Steen G Hasselbalch, Richard Dodel, Susana Aznar, Gunhild Waldemar, Tomasz Brudek, Jonas Folke · 2024
Read Autoantibody profiles in Alzheimer´s, Parkinson´s, and dementia with Lewy bodies: altered IgG affinity and IgG/IgM/IgA responses to alpha-synuclein, amyloid-beta, and tau in disease-specific pathological patterns by Luisa Knecht, Katrine Dalsbøl, Anja Hviid Simonsen, Falk Pilchner, Jean Alexander Ross, Kristian Winge, Lisette Salvesen, Sara Bech, Anne-Mette Hejl, Annemette Løkkegaard, Steen G Hasselbalch, Richard Dodel, Susana Aznar, Gunhild Waldemar, Tomasz Brudek, Jonas Folke (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11613470.txt.
Description
Luisa Knecht and co-authors profiled natural autoantibodies across three brain diseases in a 2024 paper. Alzheimer, Parkinson, and Lewy body dementia each tangle signature proteins. The immune system makes antibodies against those same proteins. The team measured their levels and grip strength in patients.
Targets were alpha-synuclein, amyloid-beta, and tau. Three antibody classes were tracked for each target. Patterns differed by disease in telling ways. Such profiles might help separate lookalike dementias. They also hint at how the immune system housekeeping of brain proteins goes wrong with age and disease over time.
Catalog record
| CREATOR | Luisa Knecht, Katrine Dalsbøl, Anja Hviid Simonsen, Falk Pilchner, Jean Alexander Ross, Kristian Winge, Lisette Salvesen, Sara Bech, Anne-Mette Hejl, Annemette Løkkegaard, Steen G Hasselbalch, Richard Dodel, Susana Aznar, Gunhild Waldemar, Tomasz Brudek, Jonas Folke |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 42 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |