Characterization of naphthoquinones as inhibitors of glutathione reductase and inducers of intracellular oxidative stress
Xiaowan Chen, Yan Ma, Ziming Yang, Dingjie Shen, Xia Li, Maowei Ni, Xiaoling Xu, Wei Chen · 2024
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Description
Xiaowan Chen and seven co-authors study a family of compounds that block a key antioxidant enzyme in a 2024 paper. That enzyme keeps the cell's chemical balance in order, and blocking it is a possible way to slow cancer growth and spread. The team tested a series of these compounds and worked out how the best one acts.
One compound blocked the enzyme both in test tubes and in living systems, in a lasting way that competes with the normal substrate. Detailed analysis showed it latches onto one or both of two binding sites. Treated cells showed more oxidative stress, failing energy centers, and changes in protein tagging. The compounds may serve research on oxidative stress.
Catalog record
| CREATOR | Xiaowan Chen, Yan Ma, Ziming Yang, Dingjie Shen, Xia Li, Maowei Ni, Xiaoling Xu, Wei Chen |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 37 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |