Targeting autophagy: polydatin’s role in inducing cell death in AML
Ping Fu, Qing Luo, Chao Wang, Liping Chen, Chang Dong, Ke Yang, Guang Wu · 2024
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Description
Ping Fu and six co-authors published a 2024 study of polydatin, a plant compound, against acute myeloid leukemia. This blood cancer grows from faulty stem cells and is the most common acute leukemia in adults. Earlier work hinted that polydatin can push cancer cells to die and can switch on autophagy, the cell’s self-cleaning system.
In a responsive leukemia cell line, polydatin slowed growth and triggered cell death. Computer modelling suggested it binds a key autophagy protein called ATG5. Tests confirmed the compound protected that protein from destruction, raising its level and switching autophagy on. In mice carrying the cancer, treatment worked and appeared safe. The authors propose polydatin as a candidate for early-stage therapy development.
Catalog record
| CREATOR | Ping Fu, Qing Luo, Chao Wang, Liping Chen, Chang Dong, Ke Yang, Guang Wu |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 34 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |