Immunoinformatics design of a multi-epitope vaccine for Chlamydia trachomatis major outer membrane proteins
Seema Shetty, Swagatika Dash, Avinash Kumar, Shashidhar Vishwanath, Suvarna G. Kini, Angela Brand · 2024
Read Immunoinformatics design of a multi-epitope vaccine for Chlamydia trachomatis major outer membrane proteins by Seema Shetty, Swagatika Dash, Avinash Kumar, Shashidhar Vishwanath, Suvarna G. Kini, Angela Brand (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11612408.txt.
Description
Seema Shetty and five co-authors designed in 2024 a computer-planned vaccine against Chlamydia trachomatis, the infection behind much blindness and sexually transmitted disease. They targeted the bacterium's major outer membrane protein, which is conserved and defines its strains. Predicted T-cell and B-cell pieces from six strains were stitched into one construct with boosters and linkers. Computer checks confirmed the design looked stable, safe and immune-stirring.
Modeling refined the construct's shape, and docking tests showed it binding firmly to an immune receptor. Simulations of the pairing stayed stable, and virtual cloning suggested easy production in bacteria. An immune simulation forecast strong antibody and killer-cell responses with a balanced helper profile. The authors stress the candidate now needs animal testing. The study shows how far vaccine design can go before any lab work begins.
Catalog record
| CREATOR | Seema Shetty, Swagatika Dash, Avinash Kumar, Shashidhar Vishwanath, Suvarna G. Kini, Angela Brand |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 56 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |