TPM4 condensates glycolytic enzymes and facilitates actin reorganization under hyperosmotic stress
Wenzhong Yang, Yuan Wang, Geyao Liu, Yan Wang, Congying Wu · 2024
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Description
Cells spend much of their energy budget maintaining the actin skeleton that holds their shape. Five authors report that when cells face very salty conditions, actin fibers are cut and a binding protein called TPM4 clumps into droplets. Those droplets gather in the enzymes that split sugar for energy, and they sit along the actin fibers, rich in stored energy carriers.
Under the same stress, cells build more actin, and removing TPM4 blocks that rebuilding. The same paired droplets appear in kidney tissue exposed to salty stress. The authors read the pattern as a stress response that ties energy production directly to skeleton repair: damage to the fibers recruits the protein, which then parks fuel-making machinery where rebuilding happens. The picture links two systems, energy supply and cell structure, that are often studied apart.
Catalog record
| CREATOR | Wenzhong Yang, Yuan Wang, Geyao Liu, Yan Wang, Congying Wu |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 64 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |