Genetic recording of transient endothelial activation in distinct alveolar capillary cells during pulmonary fibrosis
Hongxin Li, Shaohua Zhang, Xiuzhen Huang, Zhenqian Zhang, Kuo Liu, Qing-Dong Wang, Alex F. Chen, Kathy O. Lui, Kun Sun, Bin Zhou · 2024
Read Genetic recording of transient endothelial activation in distinct alveolar capillary cells during pulmonary fibrosis by Hongxin Li, Shaohua Zhang, Xiuzhen Huang, Zhenqian Zhang, Kuo Liu, Qing-Dong Wang, Alex F. Chen, Kathy O. Lui, Kun Sun, Bin Zhou (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11612399.txt.
Description
Hongxin Li and co-authors explain a genetic trick for catching lung cells in the act of changing identity, in a 2024 letter on pulmonary fibrosis. Blood vessel lining cells can, in some settings, transform into scar-forming cells, a switch called endothelial-to-mesenchymal transition. The switch is proven in heart development and disputed in adult disease: some studies see it after heart injury, others insist new scar cells come from resident ones instead.
Lung disease has its own version of the quarrel, with vessel cells in stiffened arteries apparently gaining muscle markers. Fleeting switches are easy to miss because the cell later looks fully converted. The authors' approach records the activation genetically and permanently, so even a brief transition leaves a trace. Applied to the lung's distinct capillary types during fibrosis, the method promises to settle who really changes sides.
Catalog record
| CREATOR | Hongxin Li, Shaohua Zhang, Xiuzhen Huang, Zhenqian Zhang, Kuo Liu, Qing-Dong Wang, Alex F. Chen, Kathy O. Lui, Kun Sun, Bin Zhou |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 12 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |