TAp73 and ΔTAp73 isoforms show cell-type specific distributions and alterations in cancer
Vaclav Hrabal, Michaela Stenckova, Filip Zavadil Kokas, Petr Muller, Rudolf Nenutil, Borivoj Vojtesek, Philip J Coates · 2024
Read TAp73 and ΔTAp73 isoforms show cell-type specific distributions and alterations in cancer by Vaclav Hrabal, Michaela Stenckova, Filip Zavadil Kokas, Petr Muller, Rudolf Nenutil, Borivoj Vojtesek, Philip J Coates (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11612387.txt.
Description
Vaclav Hrabal and co-authors map, in a 2024 study, where the two rival forms of the protein p73 sit in human tissues and tumors. The gene TP73, a cousin of the famous guardian TP53, makes a long form that can activate genes and a short form lacking that switch, and the two often oppose each other.
New purpose-built antibodies let the team stain each form separately. The long form marked multiciliated lining cells; the short form marked quiet basal reserve cells of squamous epithelia. In cervical cancers, the main variant appeared in most tumors, and its basal pattern tracked with lower tumor grade. The forms look like state badges.
Catalog record
| CREATOR | Vaclav Hrabal, Michaela Stenckova, Filip Zavadil Kokas, Petr Muller, Rudolf Nenutil, Borivoj Vojtesek, Philip J Coates |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 42 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |