Regulatory T cells crosstalk with tumor cells and endothelium through lymphotoxin signaling
Wenji Piao, Long Wu, Yanbao Xiong, Gregory C. Zapas, Christina M. Paluskievicz, Robert S. Oakes, Sarah M. Pettit, Margaret L. Sleeth, Keli L. Hippen, Jessica Schmitz, Philipp Ivanyi, Amol C. Shetty, Yang Song, Dejun Kong, Young Lee, Lushen Li, Marina W. Shirkey, Allison Kensiski, Aamna Alvi, Kevin H · 2024
Read Regulatory T cells crosstalk with tumor cells and endothelium through lymphotoxin signaling by Wenji Piao, Long Wu, Yanbao Xiong, Gregory C. Zapas, Christina M. Paluskievicz, Robert S. Oakes, Sarah M. Pettit, Margaret L. Sleeth, Keli L. Hippen, Jessica Schmitz, Philipp Ivanyi, Amol C. Shetty, Yang Song, Dejun Kong, Young Lee, Lushen Li, Marina W. Shirkey, Allison Kensiski, Aamna Alvi, Kevin H (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11612289.txt.
Description
Wenji Piao and a large team show how regulatory T cells, immune cells that normally calm immune responses, help tumors grow through a signaling route. Their study came out in 2024. The cells carry a surface molecule that activates a matching receptor on tumor cells and on lymphatic vessel cells.
Activating that receptor turns on a signaling pathway that speeds tumor growth and spread. Drugs that block the pathway slowed tumor growth and movement in laboratory tests. In mice, normal regulatory cells promoted melanoma growth, while cells lacking the surface molecule did not. Blocking the pathway also cut the chemical signals that recruit more regulatory cells to tumors. Fighter immune cells stayed in the tumor longer as a result. The findings suggest a strategy against tumor spread through lymph vessels.
Catalog record
| CREATOR | Wenji Piao, Long Wu, Yanbao Xiong, Gregory C. Zapas, Christina M. Paluskievicz, Robert S. Oakes, Sarah M. Pettit, Margaret L. Sleeth, Keli L. Hippen, Jessica Schmitz, Philipp Ivanyi, Amol C. Shetty, Yang Song, Dejun Kong, Young Lee, Lushen Li, Marina W. Shirkey, Allison Kensiski, Aamna Alvi, Kevin H |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 89 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |