A novel small molecule Enpp1 inhibitor improves tumor control following radiation therapy by targeting stromal Enpp1 expression
Jason R Baird, Alejandro F Alice, Roland Saito, Qingqing Chai, Minhua Han, Cindy Ng, Stephanie Han, Beth Fernandez, Sarah Ledoux, Johannes Grosse, Alan J Korman, Megan Potuznik, Venkatesh Rajamanickam, Brady Bernard, Marka R Crittenden, Michael J Gough · 2024
Read A novel small molecule Enpp1 inhibitor improves tumor control following radiation therapy by targeting stromal Enpp1 expression by Jason R Baird, Alejandro F Alice, Roland Saito, Qingqing Chai, Minhua Han, Cindy Ng, Stephanie Han, Beth Fernandez, Sarah Ledoux, Johannes Grosse, Alan J Korman, Megan Potuznik, Venkatesh Rajamanickam, Brady Bernard, Marka R Crittenden, Michael J Gough (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11612208.txt.
Description
Jason Baird and fifteen co-authors test a drug that stops tumors from muting the body's own alarm after radiation. Radiation frees DNA scraps that should trip an immune alarm, but an enzyme in tumor tissue chews those scraps up. Their 2024 study blocks that enzyme with a new small molecule.
Many cancer cells lack the enzyme, yet the tissue around tumors is rich in it. In mouse models, the blocker plus radiation shrank tumors even when cancer cells had none of the enzyme. The gain needed the alarm sensor and its signal path in healthy cells, and killer T cells did the final work. The authors say the pairing could help many patients, since the target sits in the stroma.
Catalog record
| CREATOR | Jason R Baird, Alejandro F Alice, Roland Saito, Qingqing Chai, Minhua Han, Cindy Ng, Stephanie Han, Beth Fernandez, Sarah Ledoux, Johannes Grosse, Alan J Korman, Megan Potuznik, Venkatesh Rajamanickam, Brady Bernard, Marka R Crittenden, Michael J Gough |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 63 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |