The Therapeutic Potential of Pristimerin in Osteoarthritis: Mechanistic Insights from in vitro and in vivo Studies
Li Yin, Yong Fan, Xugang Zhong, Xiang Meng, Zeju He, Zheping Hong, Jihang Chen, Qiong Zhang, Mingxiang Kong, Jiao Wang, Yu Tong, Qing Bi · 2024
Read The Therapeutic Potential of Pristimerin in Osteoarthritis: Mechanistic Insights from in vitro and in vivo Studies by Li Yin, Yong Fan, Xugang Zhong, Xiang Meng, Zeju He, Zheping Hong, Jihang Chen, Qiong Zhang, Mingxiang Kong, Jiao Wang, Yu Tong, Qing Bi (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11612203.txt.
Description
Li Yin and a large team of co-authors tested in 2024 a plant compound as a possible guard against joint cartilage loss. Osteoarthritis wears cartilage down and swells the joint lining, and plant compounds draw interest for slowing it. The compound comes from a vine long used in Chinese medicine and is known to fight swelling and cell stress. The team checked it in cell tests and in mice.
In dish tests, the compound blocked two signaling routes and reversed harmful rises in enzymes that chew up cartilage. It also partly restored a key cartilage protein. In mice with a knee injury that triggers the disease, treated animals lost less cartilage and worsened more slowly. The authors present the compound as a candidate worth further study.
Catalog record
| CREATOR | Li Yin, Yong Fan, Xugang Zhong, Xiang Meng, Zeju He, Zheping Hong, Jihang Chen, Qiong Zhang, Mingxiang Kong, Jiao Wang, Yu Tong, Qing Bi |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 40 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |