Lack of TYK2 signaling enhances host resistance to Candida albicans skin infection
Sara Miranda, Caroline Lassnig, Kristina Schmidhofer, Hrönn Kjartansdottir, Claus Vogl, Simone Tangermann, Irina Tsymala, Verena Babl, Mathias Müller, Karl Kuchler, Birgit Strobl · 2024
Read Lack of TYK2 signaling enhances host resistance to Candida albicans skin infection by Sara Miranda, Caroline Lassnig, Kristina Schmidhofer, Hrönn Kjartansdottir, Claus Vogl, Simone Tangermann, Irina Tsymala, Verena Babl, Mathias Müller, Karl Kuchler, Birgit Strobl (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11612186.txt.
Description
Sara Miranda and co-authors study a signaling kinase in skin infection by the yeast Candida albicans, in a research paper from 2024. The yeast is the most common human fungal pathogen, with illness from local to life-threatening. The kinase, TYK2, relays cytokine signals and guards against many microbes, but its role in fungal infection was unknown.
Mice that lack the kinase, or its enzyme action, resisted skin infection better than normal mice. Fungal spread fell and wounds healed faster. A distinct layer of dead neutrophils formed around the fungi. Gene reads show the kinase shapes interferon-driven genes in those cells. Its signal also aided spread to the kidneys. The role found is harmful, not protective.
Catalog record
| CREATOR | Sara Miranda, Caroline Lassnig, Kristina Schmidhofer, Hrönn Kjartansdottir, Claus Vogl, Simone Tangermann, Irina Tsymala, Verena Babl, Mathias Müller, Karl Kuchler, Birgit Strobl |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 62 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |